Peripheral blood involvement in patients with follicular lymphoma: a rare disease manifestation associated with poor prognosis
Identifieur interne : 004024 ( Main/Exploration ); précédent : 004023; suivant : 004025Peripheral blood involvement in patients with follicular lymphoma: a rare disease manifestation associated with poor prognosis
Auteurs : Clementine Sarkozy [France] ; Lucile Baseggio [France] ; Pierre Feugier [France] ; Evelyne Callet-Bauchu [France] ; Lionel Karlin [France] ; John F. Seymour [Australie] ; Laure Lebras [France] ; Anne-Sophie Michallet [France] ; Fritz Offner [Belgique] ; Olivier Dumas [France] ; Alexandra Traverse-Glehen [France] ; Martine Ffrench [France] ; Armando Lopez-Guillermo [Espagne] ; Françoise Berger [France] ; Bertrand Coififer [France] ; Pascale Felman [France] ; Gilles Salles [France]Source :
- British journal of haematology [ 0007-1048 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Follicular Lymphoma (FL) is the second most common non-Hodgkin lymphoma (NHL) subtype and its course is heterogeneous. At diagnosis, some patients with FL manifest a detectable leukaemic phase (FL-LP), but this feature has been seldom described and is poorly characterized. Among 499 patients diagnosed with FL in Lyon-Sud hospital, 37 (7.4%) had characteristic FL-LP (by cytological blood smears and flow cytometric analysis). In addition, 91/1135 FL patients from the PRIMA study presented FL-LP at study entry. In order to evaluate the outcome of this Lyon-Sud cohort, FL-LP patients were matched with 111 newly diagnosed FL without LP according to the Follicular Lymphoma International Prognostic Index (FLIPI) score, age and treatment. Presence of FL-LP was associated with shorter progression-free survival (PFS) and overall survival (OS) (P = 0.004 and P = 0.031, respectively). Presence of FL-LP and high FLIPI score remained independent prognostic factors in a Cox model for time to progression (TTP). A number of circulating lymphoma cells (CLC) >4 × 109/1 was the most significant predictor for a shorter TTP in this Cox model. The prognostic impact of FL-LP on TTP was validated in the PRIMA cohort (P = 0.0004). In conclusion, FL-LP is a rare event associated with shorter PFS and patients with CLC >4 × 109/1 have a poorer outcome. These patients should be monitored carefully to consider alternative therapeutic options.
Affiliations:
- Australie, Belgique, Espagne, France
- Auvergne-Rhône-Alpes, Catalogne, Grand Est, Lorraine (région), Province de Flandre-Orientale, Rhône-Alpes, Région flamande, Victoria (État)
- Barcelone, Gand, Lyon, Melbourne, Nancy
- Université de Gand, Université de Lorraine, Université de Melbourne
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Lyon1</s1><s2>Lyon</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Felman, Pascale" sort="Felman, Pascale" uniqKey="Felman P" first="Pascale" last="Felman">Pascale Felman</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>HCL, Service d'hematologie biologique, CHLS</s1><s2>Pierre Benite</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pierre Benite</wicri:noRegion><wicri:noRegion>CHLS</wicri:noRegion><wicri:noRegion>Pierre Benite</wicri:noRegion></affiliation></author><author><name sortKey="Salles, Gilles" sort="Salles, Gilles" uniqKey="Salles G" first="Gilles" last="Salles">Gilles Salles</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hospices Civils de Lyon (HCL), Service d'Hematologic, Centre Hospitalier Lyon Sud (CHLS)</s1><s2>Pierre Benite</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pierre Benite</wicri:noRegion><wicri:noRegion>Centre Hospitalier Lyon Sud (CHLS)</wicri:noRegion><wicri:noRegion>Pierre Benite</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Université Lyon1</s1><s2>Lyon</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno 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last="Sarkozy">Clementine Sarkozy</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hospices Civils de Lyon (HCL), Service d'Hematologic, Centre Hospitalier Lyon Sud (CHLS)</s1><s2>Pierre Benite</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pierre Benite</wicri:noRegion><wicri:noRegion>Centre Hospitalier Lyon Sud (CHLS)</wicri:noRegion><wicri:noRegion>Pierre Benite</wicri:noRegion></affiliation></author><author><name sortKey="Baseggio, Lucile" sort="Baseggio, Lucile" uniqKey="Baseggio L" first="Lucile" last="Baseggio">Lucile Baseggio</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>HCL, Service d'hematologie biologique, CHLS</s1><s2>Pierre Benite</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pierre Benite</wicri:noRegion><wicri:noRegion>CHLS</wicri:noRegion><wicri:noRegion>Pierre Benite</wicri:noRegion></affiliation></author><author><name sortKey="Feugier, Pierre" sort="Feugier, Pierre" uniqKey="Feugier P" first="Pierre" last="Feugier">Pierre Feugier</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>CHU de Nancy, Université de Lorraine</s1><s2>Nancy</s2><s3>FRA</s3><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement><settlement type="city">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Callet Bauchu, Evelyne" sort="Callet Bauchu, Evelyne" uniqKey="Callet Bauchu E" first="Evelyne" last="Callet-Bauchu">Evelyne Callet-Bauchu</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>HCL, Service d'hématologie biologique, unité de cytogénétique, CHLS</s1><s2>Pierre Benite</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pierre Benite</wicri:noRegion><wicri:noRegion>CHLS</wicri:noRegion><wicri:noRegion>Pierre Benite</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Université Lyon1</s1><s2>Lyon</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Karlin, Lionel" sort="Karlin, Lionel" uniqKey="Karlin L" first="Lionel" last="Karlin">Lionel Karlin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hospices Civils de Lyon (HCL), Service d'Hematologic, Centre Hospitalier Lyon Sud (CHLS)</s1><s2>Pierre Benite</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pierre Benite</wicri:noRegion><wicri:noRegion>Centre Hospitalier Lyon Sud (CHLS)</wicri:noRegion><wicri:noRegion>Pierre Benite</wicri:noRegion></affiliation></author><author><name sortKey="Seymour, John F" sort="Seymour, John F" uniqKey="Seymour J" first="John F." last="Seymour">John F. Seymour</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Peter MacCallum Cancer Centre and University of Melbourne</s1><s2>Melbourne, Vic.</s2><s3>AUS</s3><sZ>6 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Lebras, Laure" sort="Lebras, Laure" uniqKey="Lebras L" first="Laure" last="Lebras">Laure Lebras</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hospices Civils de Lyon (HCL), Service d'Hematologic, Centre Hospitalier Lyon Sud (CHLS)</s1><s2>Pierre Benite</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pierre Benite</wicri:noRegion><wicri:noRegion>Centre Hospitalier Lyon Sud (CHLS)</wicri:noRegion><wicri:noRegion>Pierre Benite</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Université Lyon1</s1><s2>Lyon</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Michallet, Anne Sophie" sort="Michallet, Anne Sophie" uniqKey="Michallet A" first="Anne-Sophie" last="Michallet">Anne-Sophie Michallet</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hospices Civils de Lyon (HCL), Service d'Hematologic, Centre Hospitalier Lyon Sud (CHLS)</s1><s2>Pierre Benite</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pierre Benite</wicri:noRegion><wicri:noRegion>Centre Hospitalier Lyon Sud (CHLS)</wicri:noRegion><wicri:noRegion>Pierre Benite</wicri:noRegion></affiliation></author><author><name sortKey="Offner, Fritz" sort="Offner, Fritz" uniqKey="Offner F" first="Fritz" last="Offner">Fritz Offner</name><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Ghent University</s1><s2>Ghent</s2><s3>BEL</s3><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Dumas, Olivier" sort="Dumas, Olivier" uniqKey="Dumas O" first="Olivier" last="Dumas">Olivier Dumas</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hospices Civils de Lyon (HCL), Service d'Hematologic, Centre Hospitalier Lyon Sud (CHLS)</s1><s2>Pierre Benite</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pierre Benite</wicri:noRegion><wicri:noRegion>Centre Hospitalier Lyon Sud (CHLS)</wicri:noRegion><wicri:noRegion>Pierre Benite</wicri:noRegion></affiliation></author><author><name sortKey="Traverse Glehen, Alexandra" sort="Traverse Glehen, Alexandra" uniqKey="Traverse Glehen A" first="Alexandra" last="Traverse-Glehen">Alexandra Traverse-Glehen</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Université Lyon1</s1><s2>Lyon</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>HCL, service d'Anatomie pathologique, CHLS</s1><s2>Pierre Benite</s2><s3>FRA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pierre Benite</wicri:noRegion><wicri:noRegion>CHLS</wicri:noRegion><wicri:noRegion>Pierre Benite</wicri:noRegion></affiliation></author><author><name sortKey="Ffrench, Martine" sort="Ffrench, Martine" uniqKey="Ffrench M" first="Martine" last="Ffrench">Martine Ffrench</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>HCL, service d'Anatomie pathologique, CHLS</s1><s2>Pierre Benite</s2><s3>FRA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pierre Benite</wicri:noRegion><wicri:noRegion>CHLS</wicri:noRegion><wicri:noRegion>Pierre Benite</wicri:noRegion></affiliation></author><author><name sortKey="Lopez Guillermo, Armando" sort="Lopez Guillermo, Armando" uniqKey="Lopez Guillermo A" first="Armando" last="Lopez-Guillermo">Armando Lopez-Guillermo</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Hospital Clinic</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>13 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Berger, Francoise" sort="Berger, Francoise" uniqKey="Berger F" first="Françoise" last="Berger">Françoise Berger</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Université Lyon1</s1><s2>Lyon</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>HCL, service d'Anatomie pathologique, CHLS</s1><s2>Pierre Benite</s2><s3>FRA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pierre Benite</wicri:noRegion><wicri:noRegion>CHLS</wicri:noRegion><wicri:noRegion>Pierre Benite</wicri:noRegion></affiliation></author><author><name sortKey="Coififer, Bertrand" sort="Coififer, Bertrand" uniqKey="Coififer B" first="Bertrand" last="Coififer">Bertrand Coififer</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hospices Civils de Lyon (HCL), Service d'Hematologic, Centre Hospitalier Lyon Sud (CHLS)</s1><s2>Pierre Benite</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pierre Benite</wicri:noRegion><wicri:noRegion>Centre Hospitalier Lyon Sud (CHLS)</wicri:noRegion><wicri:noRegion>Pierre Benite</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Université Lyon1</s1><s2>Lyon</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Felman, Pascale" sort="Felman, Pascale" uniqKey="Felman P" first="Pascale" last="Felman">Pascale Felman</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>HCL, Service d'hematologie biologique, CHLS</s1><s2>Pierre Benite</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pierre Benite</wicri:noRegion><wicri:noRegion>CHLS</wicri:noRegion><wicri:noRegion>Pierre Benite</wicri:noRegion></affiliation></author><author><name sortKey="Salles, Gilles" sort="Salles, Gilles" uniqKey="Salles G" first="Gilles" last="Salles">Gilles Salles</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hospices Civils de Lyon (HCL), Service d'Hematologic, Centre Hospitalier Lyon Sud (CHLS)</s1><s2>Pierre Benite</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pierre Benite</wicri:noRegion><wicri:noRegion>Centre Hospitalier Lyon Sud (CHLS)</wicri:noRegion><wicri:noRegion>Pierre Benite</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Université Lyon1</s1><s2>Lyon</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">British journal of haematology</title><title level="j" type="abbreviated">Br. j. haematol.</title><idno type="ISSN">0007-1048</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">British journal of haematology</title><title level="j" type="abbreviated">Br. j. haematol.</title><idno type="ISSN">0007-1048</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic agent</term><term>B cell neoplasm</term><term>Blood</term><term>Cancerology</term><term>Follicular lymphoma</term><term>Hematology</term><term>Human</term><term>Immunotherapy</term><term>Lymphoid neoplasm</term><term>Prognosis</term><term>Rare disease</term><term>Rituximab</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Lymphome folliculaire</term><term>Sang</term><term>Homme</term><term>Rituximab</term><term>Pronostic</term><term>Cancérologie</term><term>Immunothérapie</term><term>Hématologie</term><term>Anticancéreux</term><term>Traitement</term><term>Antigène CD20</term><term>Hémopathie maligne lymphoïde</term><term>Hémopathie lymphoïde B</term><term>Maladie rare</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Follicular Lymphoma (FL) is the second most common non-Hodgkin lymphoma (NHL) subtype and its course is heterogeneous. At diagnosis, some patients with FL manifest a detectable leukaemic phase (FL-LP), but this feature has been seldom described and is poorly characterized. Among 499 patients diagnosed with FL in Lyon-Sud hospital, 37 (7.4%) had characteristic FL-LP (by cytological blood smears and flow cytometric analysis). In addition, 91/1135 FL patients from the PRIMA study presented FL-LP at study entry. In order to evaluate the outcome of this Lyon-Sud cohort, FL-LP patients were matched with 111 newly diagnosed FL without LP according to the Follicular Lymphoma International Prognostic Index (FLIPI) score, age and treatment. Presence of FL-LP was associated with shorter progression-free survival (PFS) and overall survival (OS) (P = 0.004 and P = 0.031, respectively). Presence of FL-LP and high FLIPI score remained independent prognostic factors in a Cox model for time to progression (TTP). A number of circulating lymphoma cells (CLC) >4 × 10<sup>9</sup>/1 was the most significant predictor for a shorter TTP in this Cox model. The prognostic impact of FL-LP on TTP was validated in the PRIMA cohort (P = 0.0004). In conclusion, FL-LP is a rare event associated with shorter PFS and patients with CLC >4 × 10<sup>9</sup>/1 have a poorer outcome. These patients should be monitored carefully to consider alternative therapeutic options.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Espagne</li><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Catalogne</li><li>Grand Est</li><li>Lorraine (région)</li><li>Province de Flandre-Orientale</li><li>Rhône-Alpes</li><li>Région flamande</li><li>Victoria (État)</li></region><settlement><li>Barcelone</li><li>Gand</li><li>Lyon</li><li>Melbourne</li><li>Nancy</li></settlement><orgName><li>Université de Gand</li><li>Université de Lorraine</li><li>Université de Melbourne</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Sarkozy, Clementine" sort="Sarkozy, Clementine" uniqKey="Sarkozy C" first="Clementine" last="Sarkozy">Clementine Sarkozy</name></noRegion><name sortKey="Baseggio, Lucile" sort="Baseggio, Lucile" uniqKey="Baseggio L" first="Lucile" last="Baseggio">Lucile Baseggio</name><name sortKey="Berger, Francoise" sort="Berger, Francoise" uniqKey="Berger F" first="Françoise" last="Berger">Françoise Berger</name><name sortKey="Berger, Francoise" sort="Berger, Francoise" uniqKey="Berger F" first="Françoise" last="Berger">Françoise Berger</name><name sortKey="Callet Bauchu, Evelyne" sort="Callet Bauchu, Evelyne" uniqKey="Callet Bauchu E" first="Evelyne" last="Callet-Bauchu">Evelyne Callet-Bauchu</name><name sortKey="Callet Bauchu, Evelyne" sort="Callet Bauchu, Evelyne" uniqKey="Callet Bauchu E" first="Evelyne" last="Callet-Bauchu">Evelyne Callet-Bauchu</name><name sortKey="Coififer, Bertrand" sort="Coififer, Bertrand" uniqKey="Coififer B" first="Bertrand" last="Coififer">Bertrand Coififer</name><name sortKey="Coififer, Bertrand" sort="Coififer, Bertrand" uniqKey="Coififer B" first="Bertrand" last="Coififer">Bertrand Coififer</name><name sortKey="Dumas, Olivier" sort="Dumas, Olivier" uniqKey="Dumas O" first="Olivier" last="Dumas">Olivier Dumas</name><name sortKey="Felman, Pascale" sort="Felman, Pascale" uniqKey="Felman P" first="Pascale" last="Felman">Pascale Felman</name><name sortKey="Feugier, Pierre" sort="Feugier, Pierre" uniqKey="Feugier P" first="Pierre" last="Feugier">Pierre Feugier</name><name sortKey="Ffrench, Martine" sort="Ffrench, Martine" uniqKey="Ffrench M" first="Martine" last="Ffrench">Martine Ffrench</name><name sortKey="Karlin, Lionel" sort="Karlin, Lionel" uniqKey="Karlin L" first="Lionel" last="Karlin">Lionel Karlin</name><name sortKey="Lebras, Laure" sort="Lebras, Laure" uniqKey="Lebras L" first="Laure" last="Lebras">Laure Lebras</name><name sortKey="Lebras, Laure" sort="Lebras, Laure" uniqKey="Lebras L" first="Laure" last="Lebras">Laure Lebras</name><name sortKey="Michallet, Anne Sophie" sort="Michallet, Anne Sophie" uniqKey="Michallet A" first="Anne-Sophie" last="Michallet">Anne-Sophie Michallet</name><name sortKey="Salles, Gilles" sort="Salles, Gilles" uniqKey="Salles G" first="Gilles" last="Salles">Gilles Salles</name><name sortKey="Salles, Gilles" sort="Salles, Gilles" uniqKey="Salles G" first="Gilles" last="Salles">Gilles Salles</name><name sortKey="Traverse Glehen, Alexandra" sort="Traverse Glehen, Alexandra" uniqKey="Traverse Glehen A" first="Alexandra" last="Traverse-Glehen">Alexandra Traverse-Glehen</name><name sortKey="Traverse Glehen, Alexandra" sort="Traverse Glehen, Alexandra" uniqKey="Traverse Glehen A" first="Alexandra" last="Traverse-Glehen">Alexandra Traverse-Glehen</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Seymour, John F" sort="Seymour, John F" uniqKey="Seymour J" first="John F." last="Seymour">John F. Seymour</name></region></country><country name="Belgique"><region name="Région flamande"><name sortKey="Offner, Fritz" sort="Offner, Fritz" uniqKey="Offner F" first="Fritz" last="Offner">Fritz Offner</name></region></country><country name="Espagne"><region name="Catalogne"><name sortKey="Lopez Guillermo, Armando" sort="Lopez Guillermo, Armando" uniqKey="Lopez Guillermo A" first="Armando" last="Lopez-Guillermo">Armando Lopez-Guillermo</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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